Amoxicillin and clavulanic acid

Indications

Clavacillin Drops are indicated in the treatment of: Dogs: Skin and soft tissue infections such as wounds, abscesses, cellulitis, superficial/juvenile and deep pyoderma due to susceptible strains of the following organisms: β-lactamase-producing Staphylococcus aureus, non-β-lactamase-producing Staphylococcus aureus , Staphylococcus spp., Streptococcus spp., and E. coli . Periodontal infections due to susceptible strains of both aerobic and anaerobic bacteria. Clavacillin ® has been shown to be clinically effective for treating cases of canine periodontal disease. Cats: Skin and soft tissue infections such as wounds, abscesses, and cellulitis/dermatitis due to susceptible strains of the following organisms: β-lactamase-producing Staphylococcus aureus , non-β-lactamase-producing Staphylococcus aureus , Staphylococcus spp., Streptococcus spp., E. coli , Pasteurella multocida , and Pasteurella spp. Urinary tract infections (cystitis) due to susceptible strains of E. coli . Therapy may be initiated with Clavacillin prior to obtaining results from bacteriological and susceptibility studies. A culture should be obtained prior to treatment to determine susceptibility of the organisms to Clavacillin. Following determination of susceptibility results and clinical response to medication, therapy may be reevaluated.

Dosage and Administration

Dogs: The recommended dosage is 6.25 mg/lb (1 mL/10 lb) of body weight twice a day. Skin and soft tissue infections such as abscesses, cellulitis, wounds, superficial/juvenile pyoderma, and periodontal infections should be treated for 5-7 days or for 48 hours after all symptoms have subsided. If no response is seen after 5 days of treatment, therapy should be discontinued and the case reevaluated. Deep pyoderma may require treatment for 21 days; the maximum duration of treatment should not exceed 30 days. Cats: The recommended dosage is 62.5 mg (1 mL) twice a day. Skin and soft tissue infections such as abscesses and cellulitis/dermatitis should be treated for 5-7 days or 48 hours after all symptoms have subsided, not to exceed 30 days. If no response is seen after 3 days of treatment, therapy should be discontinued and the case reevaluated. Urinary tract infections may require treatment for 10-14 days or longer. The maximum duration of treatment should not exceed 30 days. Reconstitution Instructions - Oral Suspension: Add 14 mL of water to the 15-mL bottle and shake vigorously. To dose, push the plastic adapter into the neck of the bottle, insert the dosing syringe into the adapter, invert the bottle then slowly pull back the plunger to prescribed dose. The bottle cap fits over the plastic adapter for storage. Each mL of suspension will contain 50 mg of amoxicillin activity as the trihydrate and 12.5 mg of clavulanic acid activity as the potassium salt. Note: Any unused portion of the reconstituted suspension must be discarded after 10 days. Refrigeration of the reconstituted suspension is required. Shake well before use. Store dry powder at controlled room temperature, 68-77°F (20-25°C).

Contraindications

The use of this drug is contraindicated in animals with a history of an allergic reaction to any of the penicillins or cephalosporins.

Warnings

Safety of use in pregnant or breeding animals has not been determined. For use in dogs and cats only.

Adverse Reactions

Clavacillin contains a semisynthetic penicillin (amoxicillin) and has the potential for producing allergic reactions. If an allergic reaction occurs, administer epinephrine and/or steroids. To report suspected adverse drug events, for technical assistance, or to obtain a copy of the Safety Data Sheet, contact Dechra Veterinary Products at (866) 933-2472. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae

Description

Clavacillin (amoxicillin and clavulanate potassium for oral suspension), USP is an orally administered formulation comprised of the broad-spectrum antibiotic amoxicillin trihydrate and the β-lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid). Amoxicillin trihydrate is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many Gram-positive and Gram-negative, aerobic and anaerobic microorganisms. It does not resist destruction by β-lactamases; therefore, it is not effective against β-lactamase-producing bacteria. Chemically, it is D(-)-α-amino-p-hydroxybenzyl penicillin trihydrate. Clavulanic acid, an inhibitor of β-lactamase enzymes, is produced by the fermentation of Streptomyces clavuligerus . Clavulanic acid by itself has only weak antibacterial activity. Chemically, clavulanate potassium is potassium z-(3R,5R)-2-β-hydroxyethylidene clavam-3-carboxylate.

Other labels for this ingredient

These labels are also stored for the same active ingredient. They are not identical to the one reprinted above, and each is listed by product and set id rather than merged with it.

• Amoxicillin and Clavulanate Potassium for Oral Suspension Drops, Covetrus. Set id 0b0bfde5-7ec9-44ca-874c-f71c3384cab6.
• Umbrellin TM (amoxicillin and clavulanate potassium for oral suspension) ORAL DROPS, Aspen Veterinary Resources Ltd. Set id 27c8dc3b-0ff6-4dd5-9321-1896559b8795.
• Amoxicillin and Clavulanate Potassium for Oral Suspension Drops, Cronus Pharma LLC. Set id b5d589c3-f338-4d76-8581-abc0b5823ede.
• MWI Animal Health Betacilin Clav Drops Amoxicillin and Clavulanate Potassium AMOXICILLIN ANHYDROUS AMOXICILLIN ANHYDROUS CLAVULANATE POTASSIUM CLAVULANIC ACID VET one ® Betacilin Clav™ Drops (Amoxicillin and Clavulanate Potassium for Oral Suspension) For veterinary oral suspension For use in dogs and cats CAUTION, MWI Animal Health. Set id c4c9cc0e-79b5-4a93-8711-7c47fd9b32b3.
• CLAVAMOX ® Drops, Zoetis Inc.. Set id d342d015-0775-4f4a-98fe-e792b9895596.
• CLAVAMOX ® CHEWABLE, Zoetis Inc.. Set id 78c3cf22-9151-4f39-a857-d103eca12c93.
• Clavacillin ® (amoxicillin and clavulanate potassium tablets), USP, Dechra Veterinary Products, LLC. Set id 063b024a-c878-4230-a8fd-7decc1bcb380.
• Betacillin Clav™ Tablets (Amoxicillin and Clavulanate Potassium Tablets), MWI Animal Health. Set id feb0a9f7-8933-4a52-9b64-f4ec1ad5b462.

FDA adverse event reports

The FDA Center for Veterinary Medicine publishes the adverse event reports it receives through openFDA. The counts below are the reports naming amoxicillin and clavulanic acid as an active ingredient for each species this label names, as returned on 2026-09-16, coded by the VeDDRA reaction term the reporter chose. Reactions are counted per report, so one report can appear under several terms.

These are counts, not rates. Reporting is voluntary, the number of animals treated is not known, and a widely used product accumulates reports for that reason alone. A report records that an event followed a dose; it does not establish that the product caused it. The counts say nothing about how one product compares with another.