Clindamycin

Indications

ANTIROBE (brand of clindamycin hydrochloride) Capsules (for use in dogs only) and AQUADROPS Liquid (for use in dogs and cats) are indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below: Dogs: Skin infections (wounds and abscesses) due to coagulase positive staphylococci (Staphylococcus aureus or Staphylococcus intermedius) . Deep wounds and abscesses due to Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens . Dental infections due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens . Osteomyelitis due to Staphylococcus aureus, Bacteroides fragilis, Prevotella melaninogenicus, Fusobacterium necrophorum and Clostridium perfringens . Cats: Deep wounds and abscesses due to Staphylococcus aureus, Staphylococcus intermedius, Streptococcus spp. Deep wounds and infections due to Clostridium perfringens and Bacteroides fragilis . Dental infections due to Staphylococcus aureus, Staphylococcus intermedius, Streptococcus spp., Clostridium perfringens and Bacteroides fragilis .

Dosage and Administration

Dogs: Infected Wounds, Abscesses, and Dental Infections Oral: 2.5-15.0 mg/lb body weight every 12 hours Duration: Treatment with ANTIROBE products may be continued up to a maximum of 28 days if clinical judgment indicates. Treatment of acute infections should not be continued for more than three or four days if no response to therapy is seen Dosage Schedule Capsules ANTIROBE 25 mg , administer 1-6 capsules every 12 hours for each 10 pounds of body weight. ANTIROBE 75 mg , administer 1-6 capsules every 12 hours for each 30 pounds of body weight. ANTIROBE 150 mg , administer 1-6 capsules every 12 hours for each 60 pounds of body weight. Oral Solution ANTIROBE AQUADROPS , administer 1-6 mL/10 lbs body weight every 12 hours. Dogs : Osteomyelitis Oral : 5.0-15.0 mg/lb body weight every 12 hours Duration : Treatment with ANTIROBE is recommended for a minimum of 28 days. Treatment should not be continued for longer than 28 days if no response to therapy is seen. Dosage Schedule : Capsules ANTIROBE 25 mg , administer 2-6 capsules every 12 hours for each 10 pounds of body weight. ANTIROBE 75 mg, administer 2-6 capsules every 12 hours for each 30 pounds of body weight. ANTIROBE 150 mg, administer 2-6 capsules every 12 hours for each 60 pounds of body weight. Oral Solution ANTIROBE AQUADROPS , administer 2-6 mL/10 lbs body weight every 12 hours. Cats: Infected Wounds, Abscesses, and Dental Infections 5.0 - 15.0 mg/lb body weight once every 24 hours depending on the severity of the condition. Duration : Treatment with ANTIROBE AQUADROPS oral solution may be continued up to a maximum of 14 days if clinical judgment indicates. Treatment of acute infections should not be continued for more than three to four days if no clinical response to therapy is seen Dosage schedule : ANTIROBE AQUADROPS , to provide 5.0 mg/lb, administer 1 mL/5 lbs body weight once every 24 hours; to provide 15.0 mg/lb, administer 3 mL/5 lbs body weight once every 24 hours. ANIMAL SAFETY SUMMARY Rat and Dog Data : One year oral toxicity studies in rats and dogs at doses of 30, 100 and 300 mg/kg/day (13.6, 45.5 and 136.4 mg/lb/day) have shown clindamycin hydrochloride capsules to be well tolerated. Differences did not occur in the parameters evaluated to assess toxicity when comparing groups of treated animals with contemporary controls. Rats administered clindamycin hydrochloride at 600 mg/kg/day (272.7 mg/lb/day) for six months tolerated the drug well; however, dogs orally dosed at 600 mg/kg/day (272.7 mg/lb/day) vomited, had anorexia, and subsequently lost weight. At necropsy these dogs had erosive gastritis and focal areas of necrosis of the mucosa of the gallbladder. Safety in gestating bitches or breeding males has not been established. Cat Data : The recommended daily therapeutic dose range for clindamycin hydrochloride (ANTIROBE AQUADROPS oral solution) is 11 to 33 mg/kg/day (5 to 15 mg/lb/day) depending on the severity of the condition. Clindamycin hydrochloride (ANTIROBE AQUADROPS oral solution) was tolerated with little evidence of toxicity in domestic shorthair cats when administered orally at 10X the minimum recommended therapeutic daily dose (11 mg/kg; 5 mg/lb) for 15 days, and at doses up to 5X the minimum recommended therapeutic dose for 42 days. Gastrointestinal tract upset (soft feces to diarrhea) occurred in control and treated cats with emesis occurring at doses 3X or greater than the minimum recommended therapeutic dose (11 mg/kg/day; 5 mg/lb/day). Lymphocytic inflammation of the gallbladder was noted in a greater number of treated cats at the 110 mg/kg/day (50 mg/lb/day) dose level than for control cats. No other effects were noted. Safety in gestating queens or breeding male cats has not been established.

Contraindications

ANTIROBE Capsules and ANTIROBE AQUADROPS oral solution are contraindicated in animals with a history of hypersensitivity to preparations containing clindamycin or lincomycin. Because of potential adverse gastrointestinal effects, do not administer to rabbits, hamsters, guinea pigs, horses, chinchillas or ruminating animals.

Warnings

Keep out of reach of children. Not for human use.

Precautions

During prolonged therapy of one month or greater, periodic liver and kidney function tests and blood counts should be performed. The use of ANTIROBE occasionally results in overgrowth of non-susceptible organisms such as clostridia and yeasts. Therefore, the administration of ANTIROBE should be avoided in those species sensitive to the gastrointestinal effects of clindamycin (see

Adverse Reactions

Side effects occasionally observed in either clinical trials or during clinical use were vomiting and diarrhea. To report a suspected adverse reaction call 1-888-963-8471.

Description

ANTIROBE Capsules and ANTIROBE AQUADROPS oral solution contain clindamycin hydrochloride which is the hydrated salt of clindamycin. Clindamycin is a semisyn-thetic antibiotic produced by a 7(S)-chlorosubstitution of the 7(R)-hydroxyl group of a naturally produced antibiotic produced by Streptomyces lincolnensis var. lincolnensis. ANTIROBE Capsules (For Use in Dogs Only): 25 mg Capsule, each yellow and white capsule contains clindamycin hydrochloride equivalent to 25 mg of clindamycin. 75 mg Capsule, each dark green and white capsule contains clindamycin hydrochloride equivalent to 75 mg of clindamycin. 150 mg Capsule, each white capsule contains clindamycin hydrochloride equivalent to 150 mg of clindamycin. ANTIROBE AQUADROPS oral solution (For Use in Dogs and Cats) is a palatable formulation intended for oral administration. Each mL of ANTIROBE AQUADROPS oral solution contains clindamycin hydrochloride equivalent to 25 mg clindamycin; and ethyl alcohol, 8.64%.

Storage

Store at controlled room temperature 20° to 25°C (68° to 77°F).

Other labels for this ingredient

These labels are also stored for the same active ingredient. They are not identical to the one reprinted above, and each is listed by product and set id rather than merged with it.

• Clindamycin Hydrochloride Capsules, USP, Cronus Pharma LLC. Set id 5f35ccc3-15b3-4672-9c1f-986e8af6a0d3.
• Clindamycin Hydrochloride Tablets, FELIX PHARMACEUTICALS PRIVATE LIMITED. Set id 199f13be-92d1-4349-bd88-2b746f02d543.
• CLINTABS ® (clindamycin hydrochloride tablets), Virbac AH, Inc.. Set id 4826927c-b0ea-4772-9d0d-8e8934a598e6.
• Antirobe Aquadrops®, Zoetis Inc.. Set id a2224602-6f04-4b83-968a-8c193230998f.
• ZydaClin™ Tablets (clindamycin hydrochloride tablets), VetOne. Set id 27eb05e4-a393-4deb-96f5-23264ca467bb.
• Clindamycin HCl Oral drops, Butler Animal health Supply, LLC dba Covetrus North America. Set id 2616d89d-a927-4a0c-a781-cd31aa36cdf2.
• ZydaClin ™ ​ ​, MWI. Set id 4d70c3d4-6274-41b0-abed-0f7b076d47e7.
• Clindamycin Hydrochloride Oral Drops, FIRST PRIORITY INCORPORATED. Set id 5ea88ad7-8dbc-456b-a3cd-88bcd44c0024.
• CLINDA-GUARD ® DROPS, ASPEN VETERINARY RESOURCES. Set id 62c83acf-476e-4b35-aadf-5992349849ea.
• ClindaCure ® ​ (clindmycin hydrochloride liquid), VEDCO. Set id 882cedd8-b1df-445a-b8cf-e9bdb1341b44.

FDA adverse event reports

The FDA Center for Veterinary Medicine publishes the adverse event reports it receives through openFDA. The counts below are the reports naming clindamycin as an active ingredient for each species this label names, as returned on 2026-09-16, coded by the VeDDRA reaction term the reporter chose. Reactions are counted per report, so one report can appear under several terms.

These are counts, not rates. Reporting is voluntary, the number of animals treated is not known, and a widely used product accumulates reports for that reason alone. A report records that an event followed a dose; it does not establish that the product caused it. The counts say nothing about how one product compares with another.