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Ivermectin

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This page reprints a manufacturer label. Everything below in quotation marks is copied from , published by FDA and retrieved on 2026-09-16. Nothing has been added, reworded or left out of the sections shown. It is the manufacturer’s label, reproduced as published.

This page reprints the FDA label for by VetOne, a ivermectin product labelled for dogs. The sections below are copied from that label without change, with the set id and the date it was retrieved from DailyMed. 33 other stored labels carry the same active ingredient and are listed at the end.

The label

Product: . Manufacturer: VetOne. FDA Structured Product Label set id 860a5c9b-f984-457e-b949-e77f9b3d62bb. Label effective 2024-12-11. Retrieved 2026-09-16 from the DailyMed animal label release, and readable on DailyMed.

Indications

Cattle: Vetrimec 1% Injection is indicated for the effective treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, grubs, sucking lice, and mange mites in cattle: Gastrointestinal Roundworms (adults and fourth-stage larvae) : Ostertagia ostertagi (including inhibited O. ostertagi ), O. lyrata, Haemonchus placei, Trichostrongylus axei, T. colubriformis, Cooperia oncophora, C. punctata, C. pectinata, Oesophagostomum radiatum, Bunostomum phlebotomum, Nematodirus helvetianus (adults only), N. spathiger (adults only) Lungworms (adults and fourth-stage larvae) : Dictyocaulus viviparus Cattle Grubs (parasitic stages) : Hypoderma bovis, H. lineatum Sucking Lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus Mites (scabies): Psoroptes ovis ( syn. P. communis var. bovis), Sarcoptes scabiei var. bovis Persistent Activity Ivermectin injection has been proved to effectively control infections and to protect cattle from reinfection with Dictyocaulus viviparus and Oesophagostomum radiatum for 28 days after treatment; Ostertagia ostertagi, Trichostrongylus axei and Cooperia punctata for 21 days after treatment; Haemonchus placei and Cooperia oncophora for 14 days after treatment. Swine: Vetrimec 1% Injection is indicated for the effective treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, lice, and mange mites in swine: Gastrointestinal Roundworms: Large roundworms, Ascaris suum (adults and fourth-stage larvae), Red stomach worm, Hyostrongylus rubidus (adults and fourth-stage larvae), Nodular worm, Oesophagostomum spp. (adults and fourth-stage larvae), Threadworm, Strongyloides ransomi (adults) Somatic Roundworm Larvae: Threadworm, Strongyloides ransomi (somatic larvae) Sows must be treated at least seven days before farrowing to prevent infection in piglets. Lungworms: Metastrongylus spp. (adults) Lice: Haematopinus suis Mange Mites: Sarcoptes scabiei var. suis

Dosage and Administration

Cattle: Vetrimec 1% Injection should be given only by subcutaneous injection under the loose skin in front of or behind the shoulder at the recommended dose level of 200 mcg of ivermectin per kilogram of body weight. Each mL of Vetrimec 1% contains 10 mg of ivermectin, sufficient to treat 110 lb (50 kg) of body weight (maximum 10 mL per injection site). Swine : Vetrimec 1% Injection should be given only by subcutaneous injection in the neck of swine at the recommended dose level of 300 mcg of ivermectin per kilogram (2.2 lb) of body weight. Each mL of Vetrimec 1% contains 10 mg of ivermectin, sufficient to treat 75 lb of body weight. Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. ADMINISTRATION Cattle: Vetrimec 1% Injection is to be given subcutaneously only, to reduce risk of potentially fatal clostridial infection of the injection site. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16-gauge, 1/2 to 3/4" needle is suggested. Inject under the loose skin in front of or behind the shoulder (see illustration). When using the 50 mL, 250 mL, 500 mL or 1000 mL package size, use only automatic syringe equipment. Use sterile equipment and sanitize the injection site by applying a suitable disinfectant. Clean, properly disinfected needles should be used to reduce the potential for injection site infections. No special handling or protective clothing is necessary. Swine: Vetrimec 1% (ivermectin) Injection is to be given subcutaneously in the neck. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16- or 18- gauge needle is suggested for sows and boars, while an 18- or 20- gauge needle may be appropriate for young animals. Inject under the skin, immediately behind the ear (see illustration). When using the 50 mL, 250 mL, 500 mL or 1000 mL package size, use only automatic syringe equipment. As with any injection, sterile equipment should be used. The injection site should be cleaned and disinfected with alcohol before injection. The rubber stopper should also be disinfected with alcohol to prevent contamination of the contents. Mild and transient pain reactions may be seen in some swine following subcutaneous administration. Recommended Treatment Program Swine: At the time of initiating any parasite control program, it is important to treat all breeding animals in the herd. After the initial treatment, use Vetrimec 1% (ivermectin) Injection regularly as follows: BREEDING ANIMALS Sows: Treat prior to farrowing, preferably 7-14 days before, to minimize infection of piglets. Gilts: Treat 7-14 days prior to breeding. Treat 7-14 days prior to farrowing. Boars: Frequency and need for treatments are dependent upon exposure. Treat at least two times a year. FEEDER PIGS (Weaners/Growers/Finishers) All weaner/feeder pigs should be treated before placement in clean quarters. Pigs exposed to contaminated soil or pasture may need retreatment if reinfection occurs. NOTE: (1) Vetrimec 1% Injection has a persistent drug level sufficient to control mite infestations throughout the egg to adult life cycle. However, since the ivermectin effect is not immediate, care must be taken to prevent reinfestation from exposure to untreated animals or contaminated facilities. Generally, pigs should not be moved to clean quarters or exposed to uninfested pigs for approximately one week after treatment. Sows should be treated at least one week before farrowing to minimize transfer of mites to newborn baby pigs. (2) Louse eggs are unaffected by Vetrimec 1% Injection and may require up to three weeks to hatch. Louse infestations developing from hatching eggs may require retreatment. (3) Consult a veterinarian for aid in the diagnosis and control of internal and external parasites of swine. Special Minor Use Reindeer: For the treatment and control of warbles ( Oedemagena tarandi ) in reindeer, inject 200 micrograms ivermectin per kilogram of body weight, subcutaneously. Follow use directions for cattle as described under ADMINISTRATION. American Bison: For the treatment and control of grubs ( Hypoderma bovis ) in American bison, inject 200 micrograms ivermectin per kilogram of body weight, subcutaneously. Follow use directions for cattle as described under ADMINISTRATION. image description image description image description image description RESIDUE WARNING: Do not treat reindeer or American bison within 8 weeks (56 days) of slaughter. WARINING - NOT FOR USE IN HUMANS. Keep this and all drugs out of the reach of children. The Safety Data Sheet (SDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance, or to obtain a copy of the SDS, contact Bimeda, Inc. at 1-888-524-6332. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae. RESIDUE WARNING: Do not treat cattle within 35 days of slaughter. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal. Do not treat swine within 18 days of slaughter.

Precautions

Transitory discomfort has been observed in some cattle following subcutaneous administration. A low incidence of soft tissue swelling at the injection site has been observed. These reactions have disappeared without treatment. For cattle, divide doses greater than 10 mL between two injection sites to reduce occasional discomfort or site reaction. Use sterile equipment and sanitize the injection site by applying a suitable disinfectant. Clean, properly disinfected needles should be used to reduce the potential for injection site infections. Observe cattle for injection site reactions. Reactions may be due to clostridial infection and should be aggressively treated with appropriate antibiotics. If injection site infections are suspected, consult your veterinarian. This product is not for intravenous or intramuscular use. Protect product from light. Vetrimec 1% Injection for Cattle and Swine has been developed specifically for use in cattle, swine, reindeer, and American bison only . This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result. Restricted Drug (California) - Use Only as Directed. When to Treat Cattle with Grubs Vetrimec 1% effectively controls all stages of cattle grubs. However, proper timing of treatment is important. For most effective results, cattle should be treated as soon as possible after the end of the heel fly (warble fly) season. Destruction of Hypoderma larvae (cattle grubs) at the period when these grubs are in vital areas may cause undesirable host-parasite reactions including the possibility of fatalities. Killing Hypoderma lineatum when it is in the tissue surrounding the esophagus (gullet) may cause salivation and bloat; killing H. bovis when it is in the vertebral canal may cause staggering or paralysis. These reactions are not specific to treatment with Vetrimec 1%, but can occur with any successful treatment of grubs. Cattle should be treated either before or after these stages of grub development. Consult your veterinarian concerning the proper time for treatment. Cattle treated with Vetrimec 1% after the end of the heel fly season may be retreated with Vetrimec 1% during the winter for internal parasites, mange mites, or sucking lice without danger of grub-related reactions. A planned parasite control program is recommended. OTHER WARNINGS: Parasite resistance may develop to any dewormer, and has been reported for most classes of dewormers. Treatment with a dewormer used in conjunction with parasite management practices appropriate to the geographic area and the animal(s) to be treated may slow the development of parasite resistance. Fecal examinations or other diagnostic tests and parasite management history should be used to determine if the product is appropriate for the herd/flock, prior to the use of any dewormer. Following the use of any dewormer, effectiveness of treatment should be monitored (for example, with the use of a fecal egg count reduction test or another appropriate method). A decrease in a drug's effectiveness over time as calculated by fecal egg count reduction tests may indicate the development of resistance to the dewormer administered. Your parasite management plan should be adjusted accordingly based on regular monitoring. Environmental Safety Studies indicate that when ivermectin comes in contact with soil, it readily and tightly binds to the soil and becomes inactive over time. Free ivermectin may adversely affect fish and certain aquatic organisms on which they feed. Do not permit water runoff from feedlots or production sites to enter lakes, streams or ponds. Do not contaminate water by direct application or by the improper disposal of drug containers. Dispose of containers in an approved landfill or by incineration. As with other avermectins, ivermectin is excreted in the dung of treated animals and can inhibit the reproduction and growth of pest and beneficial insects that use dung as a source of food and for reproduction. The magnitude and duration of such effects are species and life-cycle specific. When used according to label directions, the product is not expected to have an adverse impact on populations of dung-dependent insects.

Storage

Store at 20°C to 25°C (68°F to 77°F). Protect from light. Approved by FDA under ANADA # 200-447 Manufactured by: Bimeda-MTC Animal Health Inc. Cambridge, ON Canada N3C 2W4 Distributed by: MWI Boise, ID 83705 www.VetOne.net image description

Other labels for this ingredient

These labels are also stored for the same active ingredient. They are not identical to the one reprinted above, and each is listed by product and set id rather than merged with it.

FDA adverse event reports

The FDA Center for Veterinary Medicine publishes the adverse event reports it receives through openFDA. The counts below are the reports naming ivermectin as an active ingredient for each species this label names, as returned on 2026-09-16, coded by the VeDDRA reaction term the reporter chose. Reactions are counted per report, so one report can appear under several terms.

These are counts, not rates. Reporting is voluntary, the number of animals treated is not known, and a widely used product accumulates reports for that reason alone. A report records that an event followed a dose; it does not establish that the product caused it. The counts say nothing about how one product compares with another.

Dogs: 167,897 reports

Reactions most often coded in dogs, 167,897 reports
VeDDRA reaction termReports
INEFFECTIVE, HEARTWORM LARVAE37,144
Lack of efficacy (endoparasite) - hookworm26,103
Lack of efficacy (endoparasite) - heartworm24,388
Vomiting22,793
Digestive tract disorder NOS16,656
INEFFECTIVE, ASCARIDS NOS11,819
Cardiac disorder NOS10,095
Diarrhoea9,722
Lack of efficacy - NOS8,746
INEFFECTIVE, HOOKS6,958
Lethargy (see also Central nervous system depression in 'Neurological')6,792
Lack of efficacy (endoparasite) - roundworm NOS5,058
Emesis3,220
Seizure NOS3,075
Anorexia2,884

Outcome as recorded by the reporter: Outcome Unknown 65,379; Recovered/Normal 26,054; Ongoing 17,095; Recovered with Sequela 16,914; Died 2,766; Euthanized 1,130.

Queries: reports, reactions, outcomes. Dataset: openFDA Animal and Veterinary Adverse Event Reports.

Sources

  • FDA · retrieved 2026-09-16
    “Cattle: Vetrimec 1% Injection should be given only by subcutaneous injection under the loose skin in front of or behind the shoulder at the recommended dose level of 200 mcg of ivermectin per kilogram of body weight.” (Dosage and Administration)
  • openFDA Animal and Veterinary Adverse Event ReportsFDA · retrieved 2026-09-16

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